產品屬性：
產品名稱 | PSI-697 |
規格 | 10mM*1mL in DMSO、1mg、5mg、10mg、50mg、100mg、200mg、500mg |
貨號 | EY-01Y14602 |
Cas No.: 851546-61-7
別名: N/A
化學名: N/A
分子式: C21H18ClNO3
分子量: 367.83
溶解度: DMSO: ≥ 45.8 mg/mL (124.51 mM)
儲存條件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產品描述：
PSI-697 is an oral P-selectin inhibitor with an IC50 of 125 μM[1].IC50: 125 μM (P-selectin)[1]PSI-697 inhibits the binding of a soluble human P-selectin to PSGL-1, in a reproducible concentration-dependent manner inhibiting 50% of binding at a concentration of 125 μM in vitro[1].PSI-697 (0-50 mg/kg; p.o.) significantly reduces the number of rolling leukocytes by 39% versus vehicle control[1].PSI-697 (100 mg/kg; p.o.) reduces thrombus weight by 18% relative to vehicle, without prolonging bleeding time in a rat venous thrombosis model[1].PSI-697 (30 mg/kg; p.o.; daily; 6 days) promotes thrombus resolution and decreases inflammation in a baboon model of venous thrombosis[2].PSI-697 ((30 mg/kg; i.g.; daily) decreases vein wall injury in a rat stenosis model of venous thrombosis[2].
特別提醒公司產品僅供科研使用
