產品屬性：
產品名稱 | Pyridostatin (trifluoroacetate salt) |
規格 | 1 mg、5 mg、10 mg、25 mg |
貨號 | EY-01Y14636 |
Cas No.: 1472611-44-1
別名: N/A
化學名: N/A
分子式: C31H32N8O5.C2HF3O2
分子量: 710.7
溶解度: DMF: 30 mg/mL,DMSO: 20 mg/mL,Ethanol: 5 mg/ml,PBS (pH 7.2): 5 mg/ml
儲存條件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產品描述：
Pyridostatin is a synthetic small-molecule stabilizer of G-quadruplexes, a secondary structure of DNA that usually exists in the end of the chromosome or the telomeres. It can compete for binding with the telomere-associated proteins and induce telomerase dysfunction. Pyridostatin induces DNA damage and cell cycle arrest (Kd = 490 nM) and has been shown to target the proto-oncogene Src, reducing Src protein abundance and Src-dependent motility in human breast cancer cells.11.Rodriguez, R., Miller, K.M., Forment, J.V., et al.Small-molecule-induced DNA damage identifies alternative DNA structures in human genesNat. Chem. Biol.8(3)301-310(2012)
特別提醒公司產品僅供科研使用
