產(chǎn)品屬性：
產(chǎn)品名稱 | α-Muricholic Acid-d4 |
規(guī)格 | 1 mg |
貨號(hào) | EY-01Y14766 |
Cas No.: N/A
別名: N/A
化學(xué)名: N/A
分子式: C24H36D4O5
分子量: 412.6
溶解度: DMF: 30 mg/ml,DMF:PBS (pH 7.2) (1:1): 0.5 mg/ml,DMSO: 20 mg/ml,Ethanol: 20 mg/ml
儲(chǔ)存條件: -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產(chǎn)品描述：
α-Muricholic acid-d4 is intended for use as an internal standard for the quantification of α-muricholic acid by GC- or LC-MS. α-Muricholic acid is a murine-specific primary bile acid.1,2 Dietary administration of soybean protein decreases fecal levels of α-muricholic acid in mice with high-fat diet-induced obesity, which correlates with increases in fecal Clostridium cluster XIVa, a major producer of secondary bile acids.3 Plasma, liver, and muscle levels of α-muricholic acid are increased in mice switched from a high-fat to low-fat diet.41.Eyssen, H.J., Parmentier, G.G., and Mertens, J.A.Sulfate bile acids in germ-free and conventional miceEur. J. Biochem.66(3)507-514(1976)
2.Uehara, T., Xi Peng, X., Bennett, B., et al.c-Jun N-terminal kinase mediates hepatic injury after rat liver transplantationTransplantation78(3)324-332(2004)
3.Watanabe, K., Igarashi, M., Li, X., et al.Dietary soybean protein ameliorates high-fat diet-induced obesity by modifying the gut microbiota-dependent biotransformation of bile acidsPLoS One13(8)e0202083(2018)
4.La Frano, M.R., Hernandez-Carretero, A., Weber, N., et al.Diet-induced obesity and weight loss alter bile acid concentrations and bile acid-sensitive gene expression in insulin target tissues of C57BL/6J miceNutr. Res.4611-21(2017)
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