產品屬性：
產品名稱 | Rosuvastatin lactone |
規格 | 5 mg、10 mg、25 mg、50 mg |
貨號 | EY-01Y15042 |
Cas No.: 503610-43-3
別名: N/A
化學名: N/A
分子式: C22H26FN3O5S
分子量: 463.5
溶解度: DMF: 30 mg/ml,DMSO: 15 mg/ml,Ethanol: slightly soluble
儲存條件: -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產品描述：
Rosuvastatin lactone is the lactone form of the HMG-CoA reductase inhibitor rosuvastatin .1 It is found in vivo following rosuvastatin administration.2 Rosuvastatin lactone is an inhibitor of the cytochrome P450 (CYP) isoforms CYP2C9.1 and CYP2C9.3 (IC50s = 8.52 and 4.1 μM, respectively).11.Shiozawa, A., Yamaori, S., Kamijo, S., et al.Effects of acid and lactone forms of statins on S-warfarin 7-hydroxylation catalyzed by human liver microsomes and recombinant CYP2C9 variants (CYP2C9.1 and CYP2C9.3)Drug Metab. Pharmacokinet.36100364(2021)
2.Martin, P.D., Warwick, M.J., Dane, A.L., et al.Metabolism, excretion, and pharmacokinetics of rosuvastatin in healthy adult male volunteersClin. Ther.25(11)2822-2835(2003)
特別提醒公司產品僅供科研使用
