產品屬性：
產品名稱 | SD 2590 (hydrochloride) |
規格 | 1mg、5mg |
貨號 | EY-01Y15182 |
Cas No.: 226395-93-3
別名: N/A
化學名: N/A
分子式: C22H25F3N2O7S ? HCl
分子量: 555
溶解度: DMSO: 100 mM,Water: 100 mM
儲存條件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產品描述：
SD 2590 is an inhibitor of matrix metalloproteinase-2 (MMP-2), -3, -8, -9, and -13 (IC50s = <0.1, 28.7, 1.7, 0.18, and <0.1 nM, respectively).1 It is selective for these MMPs over MMP-1 and MMP-7 (IC50s = >10,000 and 7,000 nM, respectively). SD 2590 (10 mg/kg per day) inhibits dilation of the left ventricle in rats following myocardial infarction (MI) compared to MI vehicle control animals.|1. Becker, D.P., Barta, T.E., Bedell, L.J., et al. Orally active MMP-1 sparing α-tetrahydropyranyl and α-piperidinyl sulfone matrix metalloproteinase (MMP) inhibitors with efficacy in cancer, arthritis, and cardiovascular disease. J. Med. Chem. 53(18), 6653-6680 (2010).
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