產品屬性：
產品名稱 | Neospiramycin I |
規格 | 1 mg、5 mg、10 mg |
貨號 | EY-01Y15241 |
Cas No.: 70253-62-2
別名: N/A
化學名: N/A
分子式: C36H62N2O11
分子量: 698.9
溶解度: DMSO: soluble
儲存條件: -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產品描述：
Neospiramycin I is a macrolide antibiotic and derivative of spiramycin I.1 It is active against the macrolide-sensitive KB210, but not the macrolide-resistant KB224, strain of S. aureus (MICs = 3.12 and >100 μg/ml, respectively), as well as B. cereus, B. subtilis, M. luteus, E. coli, and K. pneumoniae (MICs = 1.56, 3.12, 3.12, 0.2, 50, and 12.5 μg/ml, respectively). Neospiramycin I binds to E. coli ribosomes with an IC50 value of 1.2 μM. It protects against mortality in a mouse model of S. pneumoniae type III infection (ED50 = 399.8 mg/kg).2 1.Sano, H., Inoue, M., and ?mura, S.Chemical modification of spiramycins. II. Synthesis and antimicrobial activity of 4’-deoxy derivatives of neospiramycin I and their 12-(Z)-isomersJ. Antibiot. (Tokyo)37(7)738-749(1984)
2.Sano, H., Inoue, M., Yamashita, K., et al.Chemical modification of spiramycins. I. Synthesis of the acetal derivatives of neospiramycin IJ. Antibiot. (Tokyo)36(10)1336-1344(1983)
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