產品屬性:
產品名稱 | Nitro-PDS-Tubulysin M |
規格 | 1mg、5mg |
貨號 | EY-01Y15215 |
Cas No.: 1941168-69-9
別名: N/A
化學名: N/A
分子式: C54H73N8O11S3

分子量: 1106.4
溶解度: Soluble in DMSO
儲存條件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產品描述:
Nitro-PDS-Tubulysin M has a bioreversible linkage based on a quaternary ammonium for targeted delivery and it can improve pharmacokinetics and the therapeutic index. Nitro-PDS-Tubulysin M is used for the antibody-drug conjugates (ADC) to treat various diseases or disorders, e.g. characterized by the overexpression of a tumor antigen[1,2].ADC2-2 (anti-CD22 10F4v3 LC K149C Nitro-PDS-Tubulysin M) displays target-specific killing in WSU-DLCL2 human diffuse large B-cell lymphoma tumors with IC50 of 0.147 nM, and ADC2-1 (anti-Napi2b 10H1.11.4B LC K149C Nitro-PDS-Tubulysin M) displays target-specific killing in human ovarian cancer IGROV-1 and OVCAR-3x2.1 with IC50s of 2.07 nM, 1.004 nM, respectively[1].[1]. FLYGARE, John A, et al. Quaternary amine compounds and antibody-drug conjugates thereof. WO2016090050A1.
[2]. Staben LR, et al. Targeted drug delivery through the traceless release of tertiary and heteroaryl amines from antibody-drug conjugates. Nat Chem. 2016 Dec;8(12):1112-1119.
特別提醒公司產品僅供科研使用