產品屬性：

Cas No.: 1356019-94-7

別名: N/A

化學名: N/A

分子式: C19[13C]H22D3N7O6

分子量: 463.5

溶解度: aqueous base: slightly soluble,DMSO: slightly, heated

儲存條件: -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.

Shipping ConditionEvaluation sample solution : ship with blue ice

All other available size: ship with RT , or blue ice upon request

產品描述：

Levomefolate-13C-d3 is intended for use as an internal standard for the quantification of levomefolate by GC- or LC-MS. Levomefolate is the single (S) isomer of 5-methyltetrahydrofolic acid and an endogenous active form of folic acid .1 It donates a methyl group to homocysteine in the biosynthesis of methionine.2 Levomefolate (2 mg/kg) prevents decreases in circulating polymorphonucleates induced by methotrexate in an L1210 murine skin lymphocytic leukemia model, and it increases survival in the same model when administered in combination with methotrexate.3 Formulations containing levomefolate have been used as dietary supplements, as well as in oral contraceptives for the prevention of neural tube defects in unintended pregnancies.1.Wang, X., Shen, F., Freisheim, J.H., et al.Differential stereospecificities and affinities of folate receptor isoforms for folate compounds and antifolatesBiochem. Pharmacol.44(9)1898-1901(1992)

2.Ragsdale, S.W.Catalysis of methyl group transfers involving tetrahydrofolate and B12Vitam. Horm.79293-324(2008)

3.Simile, M.M., DeMiglio, M.R., Nufris, A., et al.l-5-formyltetrahydrofolate and l-5-methyltetrahydrofolate rescue in L1210 leukemia treated with high methotrexate dosesRes. Commun. Chem. Pathol. Pharmacol.81(2)251-254(1993)
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