產品屬性：
產品名稱 | PKUMDL WQ 2101 |
規格 | 5 mg、25 mg |
貨號 | EY-01Y15371 |
Cas No.: 304481-72-9
別名: N/A
化學名: N/A
分子式: C14H11N3O6
分子量: 317.25
溶解度: Soluble in DMSO
儲存條件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產品描述：
Negative allosteric modulator of phosphoglycerate dehydrogenase (PHGDH) (IC50 = 34.8 μM). Exhibits antitumor activity in vitro in breast cancer cells lines overexpressing PHGDH (EC50 values are 7.7 and 10.8 μM in MDA-MB-468 and HCC-70 cells, respectively). Inhibits growth of MDA-MB-468 xenografts in mice.Wang et al (2017) Rational design of selective allosteric inhibitors of PHGDH and serine synthesis with anti-tumor activity. Cell Chem.Biol. 24 55 PMID:28042046
特別提醒公司產品僅供科研使用
