產品屬性：
產品名稱 | PI3K-IN-6 |
規格 | 100mg、250mg、500mg |
貨號 | EY-01Y15488 |
Cas No.: 1842380-77-1
別名: N/A
化學名: N/A
分子式: C17H14Cl2FN9O
分子量: 450.26
溶解度: Soluble in DMSO
儲存條件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產品描述：
PI3K-IN-6 (compound 20a) is an oral active and highly selective phosphoinositide 3-kinase (PI3K) β/δ inhibitor, with IC50 values of 7.8 nM/5.3 nM for PI3K β/δ, respectively. PI3K-IN-6 (compound 20a) has potential top treat phosphatase and tensin homolog (PTEN) feficient tumors[1].
PI3Kβ|7.8 nM (IC50)|PI3Kδ|5.3 nM (IC50)|PI3Kα|850 nM (IC50)
[1]. Perreault S, et al. Discovery of a Phosphoinositide 3-Kinase (PI3K) β/δ Inhibitor for the Treatment of Phosphatase and Tensin Homolog (PTEN) Deficient Tumors: Building PI3Kβ Potency in a PI3Kδ-Selective Template by Targeting Nonconserved Asp856. J Med Chem. 2017 Feb 23;60(4):1555-1567.
特別提醒公司產品僅供科研使用
