產品屬性：

Cas No.: 1185247-12-4

別名: N/A

化學名: N/A

分子式: C21H17D8N3O2S?C4H4O4

分子量: 507.6

溶解度: DMF: soluble,DMSO: soluble,Methanol: soluble

儲存條件: -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.

Shipping ConditionEvaluation sample solution : ship with blue ice

All other available size: ship with RT , or blue ice upon request

產品描述：

Quetiapine-d8 is intended for use as an internal standard for the quantification of quetiapine by GC- or LC-MS. Quetiapine is an atypical, second generation antipsychotic compound.1,2,3 It has effects at multiple receptors, antagonizing dopamine D1, D2, and D3 receptors (Kis = 994, 379, and 340 nM, respectively), serotonin 5-HT1A, 5-HT2A, and 5-HT7 receptors (Kis = 394, 118, and 307 nM, respectively), and α1A, α1B, and α2C adrenergic receptors (Kis = 22, 15, and 29 nM, respectively).4,5 Quetiapine also potently antagonizes the histamine H1 receptor (Ki = 11 nM).51.Seeman, P.Atypical antipsychotics: Mechanism of actionCan. J. Psychiatry47(1)27-38(2002)

2.Rummel-Kluge, C., Komossa, K., Schwarz, S., et al.Second-generation antipsychotic drugs and extrapyramidal side effects: A systematic review and meta-analysis of head-to-head comparisonsSchizophr. Bull.38(1)167-177(2012)

3.Cerejeira, J., and Mukaetova-Ladinska, E.B.A clinical update on delirium: From early recognition to effective managementNurs. Res. Pract.875196(2011)

4.Richelson, E., and Souder, T.Binding of antipsychotic drugs to human brain receptors: Focus on newer generation compoundsLife Sci.68(1)29-39(2000)

5.Kroeze, W.K., Hufeisen, S.J., Popadak, B.A., et al.H1-histamine receptor affinity predicts short-term weight gain for typical and atypical antipsychotic drugsNeuropsychopharmacology28(3)519-526(2003)
特別提醒公司產品僅供科研使用