產品屬性：
產品名稱 | QL47 |
規格 | Free Sample (0.1-0.5 mg)、2mg、5mg、10mg、50mg、100mg、200mg |
貨號 | EY-01Y15617 |
Cas No.: 1469988-75-7
別名: N/A
化學名: N/A
分子式: C27H21N5O2
分子量: 447.49
溶解度: H2O: < 0.1 mg/mL (insoluble); DMSO: < 1 mg/mL (insoluble or slightly soluble)
儲存條件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產品描述：
QL47 is a potent, selective and irreversible BTK kinase inhibitor with IC50 of 7 nM.IC50 Value: 7 nMTarget: Btkin vitro: QL47 inhibits BTK kinase activity with an IC50 of 7 nM, inhibits autophosphorylation of BTK on Tyr223 in cells with an EC50 of 475 nM and inhibits phosphorylation of a downstream effector PLCγ2 (Tyr759) with an EC50 of 318 nM. In Ramos cells QL47 induces a G1 cell cycle arrest which is associated with pronounced degradation of BTK protein. QL47 inhibits the proliferation of B-cell lymphoma cancer cell lines at submicromolar concentrations [1].in vivo: N/A[1]. Wu, H., et al., Discovery of a Potent, Covalent BTK Inhibitor for B-Cell Lymphoma. ACS Chem Biol, 2014.
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