產品屬性：
產品名稱 | Minoxidil-d10 |
規格 | 500 μg、1 mg、5 mg、10 mg |
貨號 | EY-01Y15598 |
Cas No.: 1020718-66-4
別名: N/A
化學名: N/A
分子式: C9H5D10N5O
分子量: 219.3
溶解度: DMF: 2 mg/ml,DMSO: 2 mg/ml,Ethanol: 5 mg/ml,PBS (pH 7.2): 2 mg/ml
儲存條件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產品描述：
Minoxidil-d10 contains 10 deuterium atoms on the piperidine ring. It is intended for use as an internal standard for the quantification of minoxidil by GC- or LC-mass spectrometry. Minoxidil is a pyrimidine derivative that was originally developed as an anti-hypertensive agent and unexpectedly found to stimulate hair growth. Minoxidil directly affects arteriolar smooth muscle to decrease vascular resistance in part by opening ATP-sensitive potassium channels.1,2 It can activate cyclooxygenase 1 (AC50 = 80 μM), which is expressed in the dermal papilla of hair follicles, increasing prostaglandin E2 production in BALB/c 3T3 fibroblasts and human dermal papilla fibroblasts.31.Limas, C.J., and Cohn, J.N.Stimulation of vascular smooth muscle sodium, potassium--adenosinetriphosphatase by vasodilatorsCirculation Research35(4)601-607(1974)
2.Imenshahidi, M., Hadizadeh, F., Firoozeh-Moghadam, A., et al.Synthesis and vasorelaxant effect of 9-aryl-1,8-acridinediones as potassium channel openers in isolated rat aortaIran.J.Pharm.Res.11(1)229-233(2012)
3.Michelet, J.F., Commo, S., Billoni, N., et al.Activation of cytoprotective prostaglandin synthase-1 by minoxidil as a possible explanation for its hair growth-stimulating effectJournal of Investigative Dermatology108205-209(1997)
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