產品屬性：
產品名稱 | Myr-ZIP |
規格 | 1 mg、5 mg、10 mg |
貨號 | EY-01Y15779 |
Cas No.: N/A
別名: N/A
化學名: N/A
分子式: C90H154N30O17·XCF3COOH
分子量: 1928.4
溶解度: Water: 1 mg/ml
儲存條件: -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產品描述：
Myr-ZIP is a cell-permeable inhibitor of the constitutively active protein kinase C (PKC) isoform PKMζ (Ki = 0.076-2.11 μM).1,2 It also inhibits PKCα when used at a concentration of 10 μM.3 Myr-ZIP (5 μM) prevents PKC translocation to the plasma membrane induced by ionomycin in HEK293 cells expressing A-kinase anchor protein 79 (AKAP79). Myr-ZIP inhibits the conditioned place preference response to morphine in rats when administered intracranially into the nucleus accumbens core at doses of 10 and 30 nmol/0.5 μl per side.41.Yao, Y., Shao, C., Jothianandan, D., et al.Matching biochemical and functional efficacies confirm ZIP as a potent competitive inhibitor of PKMζ in neuronsNeuropharmacology64(1)37-44(2013)
2.Lee, A.M., Kanter, B.R., Wang, D., et al.Prkcz null mice show normal learning and memoryNature493(7432)419-419(2013)
3.Bogard, A.S., and Tavalin, S.J.Protein kinase C (PKC)ζ pseudosubstrate inhibitor peptide promiscuously binds PKC family isoforms and disrupts conventional PKC targeting and translocationMol. Pharmacol.88(4)728-735(2015)
4.Li, Y.-q., Xue, Y.-x., He, Y.-y., et al.Inhibition of PKMzeta in nucleus accumbens core abolishes long-term drug reward memoryJ. Neurosci.31(14)5436-5446(2011)
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