產品屬性：
產品名稱 | Phenylbutazone-d9 |
規格 | 500 μg、1 mg、5 mg |
貨號 | EY-01Y16170 |
Cas No.: 1189479-75-1
別名: N/A
化學名: N/A
分子式: C19H11D9N2O2
分子量: 317.4
溶解度: Methanol: soluble
儲存條件: -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產品描述：
Phenylbutazone-d9 is intended for use as an internal standard for the quantification of phenylbutazone by GC- or LC-MS. Phenylbutazone is a non-steroidal anti-inflammatory drug and an inhibitor of the peroxidase activity of COX (IC50 = ~100 μM in the presence of hydrogen peroxide).1 It also inhibits prostaglandin I synthase (IC50 = ~25 μM in the presence of hydrogen peroxide). Phenylbutazone (2 mg/kg) reduces increases in type II collagen levels in the inflamed joints of an equine model of LPS-induced acute synovitis.2 Formulations containing phenylbutazone have been used in the treatment of lameness in horses.1.Reed, G.A., Griffin, I.O., and Eling, T.E.Inactivation of prostaglandin H synthase and prostacyclin synthase by phenylbutazone. Requirement for peroxidative metabolismMol. Pharmacol.27(1)109-114(1985)
2.de Grauw, J.C., van Loon, J.P.A.M., van de Lest, C.H.A., et al.In vivo effects of phenylbutazone on inflammation and cartilage-derived biomarkers in equine joints with acute synovitisVet. J.201(1)51-56(2014)
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