產品屬性：
產品名稱 | L-Asparagine-d3 (hydrate) |
規格 | 1 mg、5 mg、10 mg |
貨號 | EY-01Y15975 |
Cas No.: 2483831-59-8
別名: N/A
化學名: N/A
分子式: C4H5D3N2O3·H2O
分子量: 153.2
溶解度: 1N HCl: soluble
儲存條件: -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產品描述：
L-Asparagine-d3 is intended for use as an internal standard for the quantification of L-asparagine by GC- or LC-MS. L-Asparagine is a non-essential amino acid.1 It is formed from L-aspartic acid and L-glutamine by asparagine synthetase (ASNS), and it is deamidated by L-asparaginase to produce L-aspartic acid and ammonia.2,3 L-Asparagine (0.3 mM) reverses ASNS siRNA knockdown-induced decreases in proliferation in a panel of six human cancer cell lines, indicating that both exogenous and endogenous L-asparagine promote proliferation of these cells.4 Formulations containing L-asparagine have been used as dietary supplements.1.Chiu, M.I., Taurino, G., Bianchi, M.G., et al.Asparagine synthetase in cancer: Beyond acute lymphoblastic leukemiaFront. Oncol.91480(2020)
2.Zhu, W., Radadiya, A., Bisson, C., et al.High-resolution crystal structure of human asparagine synthetase enables analysis of inhibitor binding and selectivityCommun. Biol.2345(2019)
3.Covini, D., Tardito, S., Bussolati, O., et al.Expanding targets for a metabolic therapy of cancer: L-AsparaginaseRecent Pat. Anticancer Drug Discov.7(1)4-13(2012)
4.Pathria, G., Lee, J.S., Hasnis, E., et al.Translational reprogramming marks adaptation to asparagine restriction in cancerNat. Cell Biol.21(12)1590-1603(2019)
特別提醒公司產品僅供科研使用
