產品屬性：
產品名稱 | Nexinhib20 |
規格 | 1mg、5mg、10mg、25mg |
貨號 | EY-01Y16151 |
Cas No.: 331949-35-0
別名: N/A
化學名: 4,4-dimethyl-1-(3-nitrophenyl)-2-(1H-1,2,4-triazol-1-yl)-1-penten-3-one
分子式: C15H16N4O3
分子量: 300.3
溶解度: 15mg/mL in ethanol, 30mg/mL inn DMSO
儲存條件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產品描述：
Nexinhib20 is an inhibitor of the protein-protein interaction between the small GTPase Rab27a and its effector JFC1 (IC50 = 2.6 μM).[1] It inhibits myeloperoxidase (MPO) secretion induced by granulocyte macrophage colony-stimulating factor (GM-CSF) and fMLP in isolated human neutrophils (IC50 = 0.33 μM). Nexinhib20 (30 mg/kg) reduces LPS-induced increases in plasma MPO levels, as well as LPS-induced hepatic and renal neutrophil infiltration in a mouse model of endotoxin-induced systemic inflammation.
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