產品屬性：
產品名稱 | PROTAC SGK3 degrader-1 |
規格 | 10mM*1mL in DMSO、1mg、5mg、10mg |
貨號 | EY-01Y16297 |
Cas No.: 2381320-35-8
別名: N/A
化學名: N/A
分子式: C57H73FN10O11S2
分子量: 1157.38
溶解度: DMSO: ≥ 100 mg/mL (86.40 mM)
儲存條件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產品描述：
PROTAC SGK3 degrader-1 (SGK3-PROTAC1), is a potent SKG3 degrader based on PROTAC. PROTAC SGK3 degrader-1 (0.3 μM) induces 50% degradation of endogenous SGK3 within 2 hours, with maximal 80% degradation observed within 8 hours, accompanied by a loss of phosphorylation of NDRG1( an SGK3 substrate)[1].[1]. Tovell H, et al. Design and Characterization of SGK3-PROTAC1, an Isoform Specific SGK3 Kinase PROTAC Degrader. ACS Chem Biol. 2019 Sep 20;14(9):2024-2034.
特別提醒公司產品僅供科研使用
