產品屬性：

Cas No.: 4870

別名: N/A

化學名: N/A

分子式: C15H17ClN2O2S·HCl

分子量: 361.3

溶解度: DMF: 30 mg/ml,DMSO: 30 mg/ml,DMSO:PBS (pH 7.2)(1:1): 0.5 mg/ml,Ethanol: 0.5 mg/ml

儲存條件: -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.

Shipping ConditionEvaluation sample solution : ship with blue ice

All other available size: ship with RT , or blue ice upon request

產品描述：

ML-9 was originally identified as a selective Ca2+-calmodulin-dependent myosin light chain kinase inhibitor. Concentrations from 10-100 μM are effective at inhibiting vascular smooth muscle tension and reducing intracellular Ca2+ concentrations.1 ML-9 also inhibits PKB/Akt activity with an IC50 range of 10-50 μM in rat primary adipocytes. This results in a specific inhibition of insulin-stimulated glucose transport and GLUT4/IGF II receptor translocation to the plasma membrane yet does not interfere with the antilipolytic effect of insulin.2 Additionally, ML-9 inhibits other serine/threonine kinases including PKA (IC50 = ~20 μM), p90 S6 (IC50 = ~50 μM), and MAP kinase (IC50 = ~35 μM).21.Ito, S., Kume, H., Honjo, H., et al.ML-9, a myosin light chain kinase inhibitor, reduces intracellular Ca2+ concentration in guinea pig trachealisEuropean Journal of Pharmacology486325-333(2004)

2.Smith, U., Carvalho, E., Mosialou, E., et al.PKB inhibition prevents the stimulatory effect of insulin on glucose transport and protein translocation but not the antilipolytic effect in rat adipocytesBiochemical and Biophysical Research Communications268315-320(2000)
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