產品屬性：
產品名稱 | NCGC607 |
規格 | 1mg、5mg、10mg、25mg |
貨號 | EY-01Y16842 |
Cas No.: 1462267-07-7
別名: N/A
化學名: N/A
分子式: C24H22IN3O4
分子量: 543.4
溶解度: DMF: 30 mg/mL,DMF:PBS (pH 7.2)(1:3): 0.25 mg/mL,DMSO: 25 mg/mL
儲存條件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產品描述：
NCGC607 is a salicylic acid derivative and small molecule glucocerebrosidase (GCase) chaperone. A mutation in the GCase gene is found in patients with Gaucher disease and is the most common genetic risk factor for Parkinson's disease. In induced pluripotent stem cell-derived (iPSC) macrophages from patients with Gaucher disease, NCGC607 (3 μM) restores protein levels of GCase, translocates it to the lysosome, and decreases lysosomal levels of the glycolipid glucosylceramide. In iPSC-derived cells differentiated into dopamine neurons (iDA), NCGC607 increases GCase activity and translocation to the lysosome, where it decreases glucosylceramide as well as glucosylsphingosine levels. It also rescues decreased α-synuclein levels in iDA neurons.
特別提醒公司產品僅供科研使用
