產品屬性：
產品名稱 | Trandolaprilat (hydrate) |
規格 | 1mg、5mg、10mg、25mg |
貨號 | EY-01Y17469 |
Cas No.: 951393-55-8
別名: RU 44403
化學名: (2S,3aR,7aS)-1-[(2S)-2-[[(1S)-1-carboxy-3-phenylpropyl]amino]-1-oxopropyl]octahydro-1H-Indole-2-carboxylic acid, monohydrate
分子式: C22H30N2O5 ? H2O
分子量: 420.5
溶解度: DMSO: slightly soluble,Methanol: slightly, heated, sonicated
儲存條件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產品描述：
Trandolaprilat is an angiotensin-converting enzyme (ACE) inhibitor.[1] It inhibits angiotensin I-induced contraction in isolated rat thoracic aorta (IC50 = 6.9 nM) and potentiates bradykinin-induced contraction in isolated guinea pig ileum with a 50% augmentation concentration (AC50) value of 2.7 nM. Trandolaprilat induces relaxation of norepinephrine- or potassium chloride-precontracted isolated rat thoracic aorta with intact endothelium in a concentration-dependent manner. Trandolaprilat inhibits angiotensin I-induced pressor responses in rats and dogs (ID50s = 9.9 and 7.2 μg/kg, respectively) and potentiates the bradykinin-induced depressor response in rats (ED50 = 5.5 μg/kg).[2]
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