產品屬性：
產品名稱 | LOC14 |
規格 | 1mg、5mg |
貨號 | EY-01Y17611 |
Cas No.: 877963-94-5
別名: N/A
化學名: N/A
分子式: C16H19N3O2S
分子量: 317.41
溶解度: DMSO: 25 mg/mL (78.76 mM)
儲存條件: 4°C, protect from light *Product is unstable in the solution state, it is recommended that you use it now and use it immediately
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產品描述：
LOC14 is a potent Protein disulfide isomerase (PDI) inhibitor with EC50 and Kd values of 500 nM and 62 nM, respectively. LOC14 exhibits high stability in mouse liver microsomes and blood plasma, low intrinsic microsome clearance, and low plasma-protein binding[1].LOC14 inhibits PDIA3 activity, decreases intramolecular disulfide bonds and subsequent oligomerization (maturation) of HA in lung epithelial cells[3].Kd: 62 nM (PDI)[1]LOC14 (0.01-100 μM; 24 hours) exhibits the capacity to inhibit recombinant (r)PDIA3 at an IC50 of approximately 5 μM[3].Cell Viability Assay[3]Cell Line:MTEC cellsLOC14 (orally administered by gavage; 20 mg/kg; once daily; 12-28 weeks) significantly improves motor function, attenuated brain atrophy and extended survival in the N171-82Q HD mice[2].
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