產品屬性：
產品名稱 | LY2922470 |
規格 | 10mM*1mL in DMSO、5mg、10mg、50mg、100mg |
貨號 | EY-01Y17680 |
Cas No.: 1423018-12-5
別名: N/A
化學名: N/A
分子式: C28H29NO4S
分子量: 475.6
溶解度: DMSO: ≥ 125 mg/mL (262.83 mM)
儲存條件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產品描述：
LY2922470 is a potent, selective and orally available agonist of the G protein-coupled receptor 40 (GPR40), with EC50s of 7 nM, 1 nM and 3 nM for human GPR40, mouse GPR40 and rat GPR40, respectively. LY2922470 reduces glucose levels along with significant increases in insulin and GLP-1, is potential for the treatment of type 2 diabetes mellitus (T2DM)[1]. EC50:7 nM (human GPR40), 1 nM (mouse GPR40), 3 nM (rat GPR40)[1]
[1]. Hamdouchi C, et al. The Discovery, Preclinical, and Early Clinical Development of Potent and Selective GPR40 Agonists for the Treatment of Type 2 Diabetes Mellitus (LY2881835, LY2922083, and LY2922470). J Med Chem. 2016 Dec 22;59(24):10891-10916.
特別提醒公司產品僅供科研使用
