產品屬性：
產品名稱 | LY334370 |
規格 | Free Sample (0.1-0.5 mg)、10mM*1mL in DMSO、5mg、10mg、25mg、50mg、100mg、200mg500mg、 |
貨號 | EY-01Y17788 |
Cas No.: 182563-08-2
別名: N/A
化學名: N/A
分子式: C21H22FN3O
分子量: 351.42
溶解度: DMSO: ≥ 55.5 mg/mL (157.93 mM)
儲存條件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產品描述：
LY334370 is a selective 5-HT1F receptor agonist with a Ki of 1.6 nM.Ki: 1.6 nM (5-HT1F)LY334370 has no vasoconstrictor effects on human cerebral arteries in vitro until a dose of 10-5 M, at which it produces a contraction of 8.5±5.7%; however, this is not significant[1].Following intravenous administration of LY334370 at 3 mg/kg (n=3) or 10 mg/kg (n=6) electrical stimulation evokes an increase in dural blood vessel diameter of 135±6% and 106±11%, respectively, which is not significantly different from the respective control values. LY334370 has no effect on dural blood vessel diameter per se, since the actualdural blood vessel diameter is 43±4 arbitrary units before drug and 43±4 arbitrary units 15 min after injection of LY334370 (10 mg/kg)[1].[1]. Shepheard S, et al. Possible antimigraine mechanisms of action of the 5HT1F receptor agonist LY334370. Cephalalgia. 1999 Dec;19(10):851-8.
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