產品屬性：
產品名稱 | Lats-IN-1 |
規格 | 5 mg、10 mg、25 mg |
貨號 | EY-01Y18003 |
Cas No.: 1424635-83-5
別名: N/A
化學名: N/A
分子式: C18H14N4OS
分子量: 334.39
溶解度: DMSO: 83.33 mg/mL (249.20 mM)
儲存條件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產品描述：
Lats-IN-1 is a potent and ATP-competitive inhibitor of Lats1 and Lats2 kinases. Lats-IN-1 promotes Yap-dependent proliferation in postmitotic mammalian tissues[1].The IC50 for Lats-IN-1 increases with the ATP concentration[1].Lats-IN-1 (10 μM; 24 hours) interferes with the ability of Lats kinases to phosphorylate Yap, with an EC50 of 510 nM[1].Lats-IN-1 causes Yap-dependent proliferation of murine supporting cells in the inner ear, murine cardiomyocytes, and human Müller glia in retinal organoids[1].Lats-IN-1 fosters both the G1-S and G2-M checkpoint transitions and yields supporting cells capable of transdifferentiation[1].
特別提醒公司產品僅供科研使用
