產品屬性：
產品名稱 | Altenusin |
規(guī)格 | 500μg、1mg、5mg |
貨號 | EY-01Y19758 |
Cas No.: 31186-12-6
別名: Alutenusin
化學名: 3,4',5'-trihydroxy-5-methoxy-2'-methyl-[1,1'-biphenyl]-2-carboxylic acid
分子式: C15H14O6
分子量: 290.3
溶解度: DMSO: soluble,Ethanol: soluble,Methanol: soluble
儲存條件: Store at -20°C
General tips:For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition:Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產品描述：
Altenusin is a polyphenol fungal metabolite originally isolated from the fungus Alternaria that has diverse biological activities.[1][2] It inhibits Src kinase with an IC50 value of 20 nM.[3] Altenusin inhibits fibrillization of recombinant tau fragments in vitro and phosphorylation of tau in SH-SY5Y cells expressing human P301L mutant tau when used at a concentration of 10 μM. [1] It is an agonist of the farnesoid X receptor (FXR; EC50 = 3.2 μM) that reduces blood glucose, serum insulin, and serum cholesterol levels, as well as hepatic lipogenic gene expression and steatosis, in a high fat diet-induced mouse model of obesity when administered at 30 mg/kg per day. Altenusin also has antioxidant and antifungal properties.
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