產(chǎn)品屬性：
產(chǎn)品名稱 | Ganoderic Acid C1 |
規(guī)格 | 1mg、5mg、10mg |
貨號(hào) | EY-01Y20875 |
Cas No.: 95311-97-0
別名: N/A
化學(xué)名: N/A
分子式: C30H42O7
分子量: 514.7
溶解度: DMSO: soluble
儲(chǔ)存條件: -20°C
General tips:For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition:Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產(chǎn)品描述：
Ganoderic acid C1 is a triterpenoid that has been found in G. lucidum and has diverse biological activities.1,2,3,4 It inhibits angiotensin-converting enzyme (ACE; IC50 = 745 μM).2 Ganoderic acid C1 also inhibits HIV-1 protease with an IC50 value of 180 μM.1 It reduces the proliferation of murine Lewis lung carcinoma cells but not murine Meth-A sarcoma cells (EC50s = 17 and >20 μg/ml, respectively).3 Ganoderic acid C1 (20 μg/ml) inhibits LPS-induced NF-κB phosphorylation and production of TNF-α in RAW 264.7 cells, as well as in peripheral blood mononuclear cells (PBMCs) isolated from patients with asthma.4 1.El-Mekkawy, S., Meselhy, M.R., Nakamura, N., et al.Anti-HIV-1 and anti-HIV-1-protease substances from Ganoderma lucidumPhytochemistry49(6)1651-1657(1998)
2.Hai-Bang, T., and Shimizu, K.Structure-activity relationship and inhibition pattern of reishi-derived (Ganoderma lingzhi) triterpenoids against angiotensin-converting enzymePhytochem. Lett.12243-247(2015)
3.Min, B.S., Gao, J.J., Nakamura, N., et al.Triterpenes from the spores of Ganoderma lucidum and their cytotoxicity against meth-A and LLC tumor cellsChem. Pharm. Bull. (Tokyo)48(7)1026-1033(2000)
4.Liu, C., Yang, N., Song, Y., et al.Ganoderic acid C1 isolated from the anti-asthma formula, ASHMI? suppresses TNF-α production by mouse macrophages and peripheral blood mononuclear cells from asthma patientsInt. Immunopharmacol.27(2)224-231(2015)
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